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2010.20

Publisher：liyzbs  Publish Time：Thursday, December 02, 2010 
Source：NRR

    Research and Reports
     Neurodegenerative Diseases and Neuroregeneration
1 

Two potentially specific but relevant patterns of proteomic change: response of SH-SY5Y cells to differentiation with retinoic acid followed by phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate, and susceptibility of differentiated cells to dopamine
Neural Regeneration Research
2010;5(20): 1525
Mingxiu Tian, Xing'an Li, Ming Chang, Yingjiu Zhang, Danping Wang, Hongrong Xie, Linsen Hu
Supported by:the Science and Technology Development Program of Jilin Province, No. 200505200*; the Distinguished Professor Foundation of Jilin University, No. 450011011204*

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  Research Highlights
BACKGROUND: 1. Pharmacological model of Parkinson’s disease in SH-SY5Y differentiated cells was established, and dopamine neurotoxicity-induced protein expression changes were analyzed using differential proteome. 2. Influence of cell differentiation on protein expression was investigated at proteome level, and the effect of oxidative stress on protein expression was explored. 3. Based on influence of cell differentiation on protein expression and the effect of oxidative stress on protein expression, dopamine neurotoxicity was investigated.
2 

Endoplasmic reticulum stress is involved in okadaic acid-induced tau phosphorylation and neurotoxic effects of okadaic acid
Neural Regeneration Research
2010;5(20): 1534
Lijie Feng, Yuxian Shen, Aimin Sun, Yujun Shen, Shengyun Fang, Jun Li
Supported by:he National Natural Science Foundation of China, No. 30772557*; 30870881*

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BACKGROUND: 1. Present studies have found that ER stress participated in the pathological process of many nerve degenerative diseases. However, few studies have addressed ER stress and tau abnormal phosphorylation-induced neurotoxicity. 2. This study used immunofluorescence staining, RT-PCR and Western blot assay to determine relative protein mRNA and protein levels and cellular localization, and directly verified that OA can induce SH-SY5Y cell tau protein hyperphosphorylation and cytotoxicity. Moreover, ER stress may participate in this pathological process.
3 

Apoptosis and autophagy control cell proliferation in the dentate gyrus following hippocampal lesion
Neural Regeneration Research
2010;5(20): 1541
Ju Zhou, Wei Peng, Qi Zhu, Shan Gong, Lidong Shan, Tadashi Hisamitsu, Shiyu Guo, Xinghong Jiang

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  Research Highlights
BACKGROUND: (1) This study utilized unbiased stereology quantitatively investigated nerve proliferation following hippocampal injury. Results were objective and accurate. (2) Using apoptosis and autophagy, fate turnover of proliferated hippocampal neural cells. (3) Results of the present study provides a new drug target for brain functional recovery following brain injury.
4 

Microelectrode array recordings of excitability of low Mg2+-induced acute hippocampal slices
Neural Regeneration Research
2010;5(20): 1548
Fan Yang, Xinwei Gong, Haiqing Gong, Puming Zhang, Peiji Liang, Qinchi Lu

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  Research Highlights
BACKGROUND:Mean spike frequency changes in all areas with time following application of low-Mg2+ artificial cerebrospinal fluid. DG: dentate gyrus. ① Very little is known about ex vivo hippocampus using multi-electrode-array ② This study recorded electric activity at several site using multi-electrode-array, directly observed hippocampal sections to analyze the inner network structure.
     Traditional Chinese Medicine and Neuroregeneration
5 

Potent protection of Danshensu (β-3, 4-dihydroxyphenyl-lactic acid) against excitotoxic effects of maternal intragastric administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain
Neural Regeneration Research
2010;5(20): 1559
Jingen Shen, Lijian Yu, Rundi Ma, Yongping Zhang, Xiaoyu Zhang, Juanzhi Fang, Tingxi Yu

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  Research Highlights
BACKGROUND:Ten animals were used in each group. Vertical error bars represent SEM. The repeated-measures analysis with an unstructured variance covariance structure model was used to analyze the data from Y-maze discrimination learning test. Comparisons of P Values
6 

Antidepressant effect of bioactive compounds from Paecilomyces tenuipes in mice and rats
Neural Regeneration Research
2010;5(20): 1568
Hongwei Kan, Liang Ming, Chunru Li, Hongxing Kan, Bei Sun, Yan Liang
Supported by:the Grant of Anhui Education Department, No. 2004KJ194ZD*; the Grant of Anhui Science & Technology Department, No. 04023048*

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  Research Highlights
BACKGROUND:The comparison of monoamine oxidase A inhibitor moclobemide as control gold standard found that bioactive compounds from Paecilomyces tenuipes can significantly improve depression by improving hippocampal neurotransmitter mineralcorticoid receptor and glucocorticoid receptor mRNA expression, with potential anti-depressive effects.
7 

Tanshinone IIa antagonizes spinal ischemia/reperfusion injury by interfering with upstream glutamic acid factor
Neural Regeneration Research
2010;5(20): 1573
Li Zhang, Xiang Lin, Weinan Liu, Jianhua Lin
Supported by:the National Natural Science Foundation of China, No.30572401*, No.30973765*; the Natural Science Foundation of Fujian Province, No.2008J0094*; the Science and Technology Activity of Abroad Scholars, Ministry of Personnel, No. [2006]164*; Scientific Research Foundation for Talents of Fujian Province, No. 1401*

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  Research Highlights
BACKGROUND:1Previous studies focus on neuroprotective effect of tanshinone in rats. This study observed Glu transporter function and determined Na+-K+-ATPase activity in rats following ischemia/reperfusion injury to provide experimental data and evidence for tanshinone clinical application. 2This study utilized vascular casting and digital imaging techniques for the first time to establish and identify the model of spinal ischemia/reperfusion injury to investigate the effect of tanshinone, a Chinese drug that activates blood circulation to dissipate blood stasis, on spinal ischemia/reperfusion injury


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