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2010.24

Publisher:liyzbs  Publish Time:Friday, January 14, 2011 
Source:NRR

    Research and Reports
     Neurodegenerative Diseases and Neuroregeneration
1 

Event-related potential N170 for early diagnosis of face recognition impairment in Parkinson's disease
Neural Regeneration Research
2010;5(24): 1845
Jing Hou, Haihong Wang, Tong Chen, Zhenfu Wang

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  Research Highlights
The present study assessed cognitive function in Parkinson’s disease (PD) patients using neuropsychological scales and analyzed N170 of visuospatial function impairment (VPI) in PD. Results showed that Montreal cognitive assessment can be used for assessing cognitive impairment when visuospatial functioning is changed during the early stage of PD. Face recognition has clinical significance for detecting changes in visuospatial functioning.
2 

Dynamic expression of P-glycoprotein in the CA1, CA3 and dentate gyrus of the rat hippocampus following lithium-pilocarpine-induced status epilepticus
Neural Regeneration Research
2010;5(24): 1851
Shuda Chen, Jueqian Zhou, Xiuling Liang, Ziyi Chen, Libai Yang,
Liemin Zhou
Supported by:the Science and Technology Foundation of Guangdong Province, No. 2009B060700049*, 2008B060600063*; the National Natural Science Foundation of China, No. 10671213

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  Research Highlights
This study verified that high expression of P-glycoprotein was determined in the rat hippocampus at 1 and 60 days following lithium-pilocarpine-induced status epilepticus in the levels of tissue, gene and protein. This indicated that epileptic seizures could induce overexpression of P-glycoprotein. This study sought to investigate the correlation of seizure frequency and P-glycoprotein expression, but positive results were not obtained.
3 

Proliferation changes in hippocampal neurons following pilocarpine-induced intractable epilepsy in adult rats
Neural Regeneration Research
2010;5(24): 1858
Lancai Xiong, Xuejun Deng, Fang Wang, Chunling Du, Shenggang Sun

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  Research Highlights
The present study used rat models of pilocarpine-induced intractable epilepsy to investigate the change and significance of neurogenesis in the hippocampus following pilocarpine-induced intractable epilepsy. Results showed that the newly formed cells were significantly reduced in the intractable epilepsy group than in the common epilepsy group, indicating that intractable epilepsy leads to reduced neurogenesis.
     Traditional Chinese Medicine and Neuroregeneration
4 

Meta-analysis of 20 clinical, randomized, controlled trials of acupuncture for depression
Neural Regeneration Research
2010;5(24): 1862
Ling Fan, Wenbin Fu, Nenggui Xu, Jianhua Liu, Aihua Ou, Yanwen Wang
Supported by:the National Natural Science Foundation of China, No. 30772828*; the Natural Science Foundation of Guangdong Province, No. 07004846*; the Special Scientific Research Foundation of Ministry of Education for Doctoral Research Project of Combined Program of Colleges and Universities, No. 20094425110005*; the Science and Technology Development Program of Guangdong Provincial Science and Technology Department, No. 2008B030301206

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  Research Highlights
① The present study utilized evidence-based medicine approach to evaluate the clinical evidence for treating depression with acupuncture, providing quantitative evidence for acupuncture in the treatment of depression. ② The present study included a total of 20 high quality randomized controlled trials and 2 787 patients from the aspect of depressive state (depressive symptoms). Through the test of heterogeneity, sensitivity analysis, the calculation of combined effect size and the significant test, the detection of publication bias, the efficacy of acupuncture to treat depression was systematically evaluated.
5 

Luteolin protects PC12 cells from rotenone-induced apoptosis
Neural Regeneration Research
2010;5(24): 1870
Lihong Zhu, Renbin Qi, Huadong Wang, Wei Bi, Zhigang Wang, Qi Zeng, Yanru Zhao, Daxiang Lu
Supported by:the grant from the Leading Academic Discipline Program, National 211 Project of Jinan University (the 3rd phase) *; the Science and Technology Project of Guangzhou City, No 2008J1-C181-1*; the Fundamental Research Funds for the Central Universities, No. 21609425

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  Research Highlights
Luteolin protects PC12 cells against rotenone-induced apoptosis by decreasing cleaved caspase-3 expression. This provides evidence for primary neurons in vitro study and application of luteolin in models of Parkinson’s disease.
6 

Thrombolytic activity of cheonggukjang kinase in recovery from brain damage in a rat cerebral embolic stroke model
Neural Regeneration Research
2010;5(24): 1875
Angella M Anthony Jalin, Chae Kwan Lee, Chae Yeon Lee, A Reum Kang, Chung Mu Park, Jae Ho Cha, Jeong Hwan Kim, Soo Woong Lee,
Young Sun Song, Jong Tae Lee, Sung Goo Kang
Supported by:the National Research Foundation of Korea, funded by the Korean Ministry of Education, Science and Technology, No. 2007-0055330*; Inje University Research Grant (2008)

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  Research Highlights
Cheonggukjang kinase (CGK) is not a plasminogen activator, but may acts as a plasmin-like protease that can directly dissolve fibrin clots. CGK may exert neuroprotective effects against cerebral embolic stroke insult. CGK may be more efficacious for clot-dissolving than is r-tPA.
7 

Side effects of different doses of ephedrine in rats with cerebral ischemia/reperfusion injury
Neural Regeneration Research
2010;5(24): 1883
Ling Liu, Liyun Lin, Nong Xiao, Yuxia Chen, Siyuan Chen
Young Sun Song, Jong Tae Lee, Sung Goo Kang

  |Abstract|HTML|PDF|Supplementary |Editor's Choice
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  Research Highlights
Ephedrine exhibited side effects on the cerebrum, heart, liver and kidney in rats following cerebral ischemia/reperfusion in a dose dependent manner.


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