2011.06 - CRTER NRR BRM JCS SCIR TCT TCMC TOGT

2011.06

Publisher：liyzbs Publish Time：Saturday, March 12, 2011
Source：NRR

Research and Reports

Traditional Chinese Medicine and Neuroregeneration

Neuroprotective effect of epigallocatechin-3-gallate on hemisection-induced spinal cord injury in rats
Neural Regeneration Research
2011;6(6): 405
Fengjun Deng, Rubing Li, Yingbao Yang, Dan Zhou, Qian Wang, Jiangping Xu

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Research Highlights

(1) Epigallocatechin-3-gallate (EGCG), a naturally occurring compound in green tea, has been widely used as an antioxidant agent. EGCG can relieve neuronal and axonal injury following acute spinal cord injury, significantly inhibit inflammation, suppress oxidation, and reduce apoptosis in acute spinal cord injury . (2) EGCG at the 100 mg/kg dosage exhibited similar neuroprotective effects as methylprednisolone sodium succinate following acute spinal cord injury.

Effects of Rhizoma Acori Tatarinowii extracts on gamma-aminobutyric acid type A receptor alpha 1 subunit brain expression during development in a recurrent seizure rat model
Neural Regeneration Research
2011;6(6): 412
Liqun Liu, Ding'an Mao, Keqiang Chi, Xingfang Li, Tao Bo, Jinming Guo, Zhuwen Yi
Supported by: the Natural Science Foundation of Hunan Province, No. 09JJ6032*

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Research Highlights

Using immunohistochemical and western blot analyses, the present study observed animal models of seizures and changes in gamma-aminobutyric acid type A receptor alpha 1 subunit protein expression in the cerebral cortex and hippocampus of rats with brain injury following treatment with Rhizoma Acori Tatarinowii extracts. A semi-quantitative scoring method was used to assess action mechanisms of Rhizoma Acori Tatarinowii extracts on pathological brain injury.

NeuroAid (MLC601) versus piracetam in the recovery of post-infarct homonymous hemianopsia
Neural Regeneration Research
2011;6(6): 418
Kavian Ghandehari, Zahra Izadi Mood, Saeed Ebrahimzadeh, David Picard, Yue Zhang

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Research Highlights

1. To compare the effects of two neuroprotective drugs, NeuroAid (MLC601) and piracetam, on post-infarct recovery from isolated pure homonymous hemianopsia (HH), a randomized, prospective, comparative pilot study was performed in 40 patients with posterior cerebral artery territory infarction. 2. MLC601 was superior to piracetam in recovery of post-stroke HH. Posterior cerebral artery territory infarction presenting with HH constituted a subgroup of stroke patients, who benefited from treatment with MLC601.

Effects of sericin on heme oxygenase-1 expression in the hippocampus and cerebral cortex of type 2 diabetes mellitus rats
Neural Regeneration Research
2011;6(6): 423
Zhihong Chen, Yaqiang He, Wenliang Fu, Jingfeng Xue
Supported by:a Grant from Department of Education of Hebei Province, No. 2006301*; a Grant from Department of Technology of Hebei Province, No. 08276101D-19*

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Research Highlights

This study firstly investigated effects of sericin on morphology and heme oxygenase-1 expression in the hippocampus and cerebral cortex of type 2 diabetes mellitus rats. Results demonstrated that sericin plays a protective effect on the nervous system by relieving the high expression of heme oxygenase-1 following diabetes mellitus. Sericin obviously decreased blood glucose, served as natural protein, avoided chemical drugs-induced toxicity and side effects, and would bring about good social effects.

Acupuncture and Moxibustion and Neuroregeneration

Cerebral functional imaging of Waiguan (SJ 5) acupoint specificity using single-photon emission computed tomography
Neural Regeneration Research
2011;6(6): 428
Yong Huang, Yangjia Lu, Ganlong Li, Xinsheng Lai, Hong Zhang, Chunzhi Tang, Junjun Yang, Gustav Wik
Supported by:the National 973 Program of China, No. 2006CB504505*; the National Natural Science Foundation of China, No. 90709027*

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Research Highlights

(1) This study contained the comparison of acupuncture-non-acupuncture, true and sham acupuncture, as well as true and sham point, and fully analyzed the relative specificity of acupuncture point. (2) The present study used SPM data analysis and three-dimensional reconstruction in the brain. (3) Compared with animal study, this study used human as subjects, which can precisely provide image and data.

Formation mechanism of propagated sensation along the meridians, as verified by cortical somatosensory-evoked potential topographic maps
Neural Regeneration Research
2011;6(6): 435
Jinsen Xu, Xiaohua Pan, Shuxia Zheng, Xianglong Hu, Zheyan Sa
Supported by:the National Natural Science Foundation of China, No. 30973720*; the Science Research Founda-tion of Ministry of Health & United Fujian Provincial Health and Education Project for Tackling the Key Research of China, No. WKJ2005-2-004*

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Research Highlights

The present study observed propagated sensation along meridians, as well as simulated changes in functional activity of somatosensory area I, using cortical somatosensory-evoked potential topographic maps. These results help to objectively verify the hypothesis of the peripheral driver stimulating theory.

Meta-analysis

Acupuncture for neurological disorders in the Cochrane reviews: characteristics of included reviews and studies
Neural Regeneration Research
2011;6(6): 440
Deren Wang, Weimin Yang, Ming Liu

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Research Highlights

(1) Methodological flaws were common in previously published acupuncture trials, such as unclear methods of randomization and few blinded trials. Double blinding was hardly achieved, because those who performed the intervention were aware of patient allocation due to the nature of the intervention. One solution is the blinded outcome evaluation, i.e. the evaluation of the outcome measures were performed by different persons blinded to the experimental protocols. (2) Acupuncture for stroke was assessed frequently in the Cochrane database. However, its effectiveness was not firmly concluded. In contrast, of the three reviews on headache, two concluded that acupuncture was effective. The remaining reviews suggested no positive conclusions due to small sizes or low methodological quality.

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