Xian Qu1, Chunying Li1, Hongchang Liu2, Chang Su1

1Basic Medical College of Beihua University, Jilin 132013, Jilin Province, China
2Jilin Provincial Qian Wei Hospital, Changchun 130000, Jilin Province, China

Abstract
Four weeks of uncertain stress was used to establish an animal model of chronic stress. Basic fibroblast growth factor was injected daily for 15 days following stress induction. Cell morphology in the hippocampal CA3 region of chronic stress mice revealed cell damage. Nitric oxide content and calcium concentration were significantly increased in the hippocampus, and learning and memory functions were significantly decreased. After basic fibroblast growth factor intervention, Ca2+ overload was decreased and neuronal damage was relieved in hippocampal neurons, which improved learning and memory functions in chronic stress mice. Latency was prolonged and the number of errors was decreased in a passive avoidance test.
Key Words: basic fibroblast growth factor; chronic stress; step-down test; passive avoidance test; learning and memory; nitric oxide; neural regeneration

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