Shoucai Zhao, Zhaohu Chu, Lingsong Ma, Yinong Chen, Lei Wang, Benxiao Wang, Zili Huang, Jun Zhang

Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China

Abstract
This study sought to examine neuroglobin (NGB) in the serum of acute cerebral infarction patients with double-antibody sandwich enzyme-linked immunosorbent assay to identify all risk factors, calculate infarct size, assess neurological impairment, and analyze the relation between NGB and each of these factors. The double-antibody sandwich assay indicated that levels of NGB in serum were unaltered within 6 hours following acute cerebral infarction compared with normal levels. NGB levels then underwent a distinct change, peaking at 24 hours then returning to normal levels in 72 hours. The results suggest that the level of NGB might be related to infarct size and low-density lipoprotein at 24 hours after acute cerebral infarction. There were no significant differences in neurological impairment scores and infarct size at different periods following infarction. The findings indicated that the level of NGB in serum of acute cerebral infarction patients was correlated with infarct time.
Key Words: neuroglobin; acute cerebral infarction; onset time; morbidity; infarct size; neurological impairment score

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