Diagnostic Imaging Centre, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia

Abstract
Because functional magnetic resonance imaging can be used for dynamic observation of functional cortical changes after brain injuries, we followed up functional magnetic resonance imaging ma-nifestations of a language-related brain network in a low-grade glioma patient. Disease progression and therapy during a 3-year period were followed up at different time points: before and after reo-peration, after radiation therapy, and 1 year after irradiation. During the whole 3-year follow-up period, the patient exhibited no neurological deficits while functional magnetic resonance imaging revealed different topologies of the language-related brain network. During disease progression and after irradiation, the language-related brain network was extended or completely transferred to the nondominant (right) hemisphere. In addition, after reoperation and 1 year after irradiation, language areas were primarily found in the language dominant (left) hemisphere. Our results suggest a high level of adaptability of the language-related cortical network of the bilateral hemispheres in this low-grade glioma patient.
Key Words: functional magnetic resonance imaging; low-grade glioma; cortical changes; language-related brain network