Haitao Xu1, Yuying Jiang2, Xiuhong Qin1, Lihui Si3, Jie Zhao4, Lijuan Liu5, Yazhen Wu1

1Department of Ophthalmology, Second Clinical Hospital of Jilin University, Changchun 130041, Jilin Province, China
2Department of Ophthalmology, China-Japan Friendship Hospital, Jilin University, Changchun 130033, Jilin Province, China
3Department of Gynaecology and Obstetrics, Second Clinical Hospital of Jilin University, Changchun 130041, Jilin Province, China
4Changchun Medical College, Changchun 130013, Jilin Province, China
5Emergency Center of Changchun, Changchun 130021, Jilin Province, China

Abstract
Following granulocyte colony-stimulating factor (G-CSF) treatment, the growth of processes in cultured rat retinal ganglion cells (RGCs) in vitro, expression of growth associated protein 43, and expression of microtubule-associated protein 2 mRNA expression were significantly increased. In contrast, RhoA/Rock protein content was significantly reduced by G-CSF treatment. These results indicate that G-CSF promotes the growth of processes in RGCs and increases the expression of growth-associated protein 43 and microtubule-associated protein 2 mRNA by inhibiting the RhoA/Rock pathway, thereby benefiting axonal repair in RGCs exposed to hypoxia.
Key Words: granulocyte colony-stimulating factor; ganglion cells; growth-associated protein 43; microtubule-associated protein 2; axons; neural regeneration

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