2011.33 - CRTER NRR BRM JCS SCIR TCT TCMC TOGT

2011.33

Publisher：tengyjzxb Publish Time：Thursday, December 15, 2011
Source：NRR

Research and Reports

Traditional Chinese Medicine and Neuroregeneration

Protective effects of Ginkgo biloba extract on 6-hydroxydopamine-induced apoptosis in PC12 cells**★
Neural Regeneration Research 2011;6(33):2565-2572
Jie Wang1, Yanbo Cheng2, Jiale Yin1, Qian Lu1, Xingshun Xu2, Xiaoxing Yin1
Supported by:the National Natural Science Foundation of China, No. 30700245*; Natural Science Research Foundation of Jiangsu Province Universities, No. Jsbl0702*

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Research Highlights

BACKGROUND:Ginkgo biloba extract can significantly reduce the effects of oxidative stress state induced by 6-hydroxydopamine in PC12 cells. The extract modulates gene expression and signaling downstream of caspase-3 activation, thus suppressing PC12 cell apoptosis induced by 6-hydroxydopamine.

Xuebijing alters tumor necrosis factor-alpha, interleukin-1beta and p38 mitogen activated protein kinase content in a rat model of cardiac arrest following cardiopulmonary resuscitation*★
Neural Regeneration Research 2011;6(33):2573-2576
Haifeng Li, Mingli Sun, Yaxin Yu, Xiaoliang Liu
Supported by:a grant from the Science and Technology Department of Jilin Province, No. 200705172*

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Research Highlights

BACKGROUND:Expression of tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase were increased in the brain after cardiac arrest and cardiopulmonary resuscitation. Xuebijing, a Chinese herb compound preparation, dose-dependently reduced the expression of tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase, and attenuated brain neuronal injury, induced by hypoxia and reperfusion during cardiopulmonary resuscitation.

Effects of Fujian tablet on Nogo-A mRNA expression and plasticity of the corticospinal tract in a rat model of focal cerebral ischemia*☆
Neural Regeneration Research 2011;6(33):2577-2581
Wei Liu1, Yonghong Zhou2, Qing Jia3, Bingbing Han4, Guoli Zhang5
Supported by:the National Natural Science Foundation of China, No. 30801470*

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Research Highlights

BACKGROUND:By detecting corticospinal tract plasticity and cervical cord microenvironment in rats with focal cerebral ischemia, this study demonstrated that Fujian tablet can improve neurological function following cerebral infarction through the inhibitory effect on Nogo-A mRNA expression to promote corticospinal tract plasticity.

Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression*★
Neural Regeneration Research 2011;6(33):2582-2588
Yuanyuan Zhang, Jianjun Jia, Liping Chen, Zhitao Han, Yulan Zhao, Honghong Zhang, Yazhuo Hu
Supported by:a grant from Science and Technology Bureau of Beijing, No. Z090507017709030*

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Research Highlights

BACKGROUND:Shuyusan improved depression symptoms in a rat model of depression, as well as increased behavioral scores. Results suggested involvement of 5-hydroxytryptamine metabolite and precursor levels, as well as the regulation of 5-hydroxytryptamine metabolism.

Sidiming attenuates morphine withdrawal syndrome and nitric oxide (synthase) levels in morphine-dependent rats and rhesus monkeys*★
Neural Regeneration Research 2011;6(33):2589-2599
Zheng Yang, Renbin Huang, Jianchun Huang, Shijun Zhang, Xing Lin, Yang Jiao, Weizhe Jiang
Supported by:the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 0575066*

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Research Highlights

BACKGROUND:Results from the present study showed that Sidiming administration results in attenuated withdrawal syndrome and body mass loss in morphine-dependent rats and rhesus monkeys. The underlying mechanisms are thought to be associated with decreased regulation of nitric oxide release and inhibition of nitric oxide synthase activity.

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