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2012.3

Publisher:tengyjzxb  Publish Time:Friday, February 03, 2012 
Source:NRR

    Research and Reports
     Traditional Chinese Medicine and Neuroregeneration

1

Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model*☆○
Neural Regeneration Research 2012;7(3):165-170
Yinghong Li1, Zhengzhi Wu1, 2, Xiaowei Gao1, Qingwei Zhu1, Yu Jin1, Anmin Wu1, Andrew C. J. Huang3
Supported by:the National Natural Science Foundation of China (Influence of Anchanling on endoplasmic reticulum stress and ubiquitin-proteasome system in PD model), No. 30772757.

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BACKGROUND:Anchanling, a Chinese medicine, mainly composed of magnolol, reduces pathology in a lactacystin-induced Parkinson's disease model.

2

Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats*****☆
Neural Regeneration Research 2012;7(3):171-175
Zheng Gong1, 2, 3, Lijuan Yang1, 2, 3, Hongmei Tang1, 2, 3, Rui Pan4, Sai Xie1, 2, 3, Luyan Guo1, 2, 3, Junbin Wang1, 2, 3, Qinyin Deng1, 2, 3, Guoyin Xiong1, 2, 3, Yanyan Xing1, 2, 3, Jun Dong1, 2, 3
Supported by: the Natural Science Foundation of Guangdong Province, No. 9151040701000, 061050246; the Science and Technology Project of Guangdong Province, No. 2010B030700016; the Science and Technology Project of Guangzhou, No. 2010Y1-C291; the National Natural Science Foundation of China, No. 81171134.

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BACKGROUND:Curcumin and gp120 V3 loop co-cultured with hippocampal neurons increased the mitochondrial membrane potential, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury in rats.

3

Neuroprotective effects of total saponins from Rubus parvifolius L. on cerebral ischemia/ reperfusion injury in rats*☆
Neural Regeneration Research 2012;7(3):176-181
Jisheng Wang1, Fang Zhang1, Li Tang1, Liqiong Sun1, Xiaolin Song1, Lisha Cao1, Zongyin Qiu2, Chenglin Zhou2
Supported by:the Mianyang Science and Technology Commission, No. 06S042-7.

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BACKGROUND:This study showed that, total saponins from Rubus parvifolius L. can decrease neurological impairment, reduce cerebral infarct volume, diminish pathological changes in rat models of local cerebral infarction and reperfusion. The possible mechanism may be that total saponins from Rubus parvifolius L. upregulated the expression of the anti-apoptotic factor Bcl-2, and downregulated the expression of the pro-apoptotic factor Bax.

4

Effect of single-use versus combined-use moschus and diazepam on expression of amino acid neurotransmitters in the rat corpus striatum
Neural Regeneration Research 2012;7(3):182-186
Na Zhang1, 2, Ping Liu1, Xinrong He1

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BACKGROUND:Results from the present study showed that moschus promoted inhibition effects of diazepam on the brain, as determined by detection of excitatory neurotransmitters, aspartate, glutamate, inhibitory neurotransmitters, glycine, and γ-aminobutyric acid in the corpus striatum of rats.

5

Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression*★
Neural Regeneration Research 2012;7(3):187-190
Wentao Fan, Qian Wang, Yongmei Yan
Supported by: the Major Program of "13115" Science and Technology Innovation Project (Preclinical study of Xingnao Jieyu capsule), No. 2010ZDKG-65.

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BACKGROUND:Xingnao Jieyu capsules can promote hippocampal and frontal lobe neuronal proliferation and improve neurological function of rats with post-stroke depression. Xingnao Jieyu at high doses exhibits similar ef-fects to the traditional antidepressant Prozac.


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